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During orgasms, the body releases a mix of neurotransmitters and hormones, including:
Dopamine: Associated with pleasure and reward.
Endorphins: Natural painkillers that induce euphoria.
Oxytocin: Promotes bonding and social connection (often called the "love hormone").
Serotonin: Contributes to mood stabilization and feelings of well-being.
Prolactin: Induces relaxation and post-orgasm satiety (linked to the refractory period).
Norepinephrine/Adrenaline: Increases heart rate and arousal (part of the sympathetic nervous system response).

The concept of "opposite" hormones is nuanced, as hormones interact in complex ways. However, based on antagonistic effects:
Dopamine Cortisol: Cortisol (a stress hormone) counteracts dopamine’s pleasure/reward effects.
Endorphins Substance P: Substance P transmits pain signals, opposing endorphins' pain-relieving role.
Oxytocin Adrenaline/Cortisol: Stress hormones like adrenaline/cortisol reduce social bonding and induce fight-or-flight responses.
Prolactin Dopamine: Dopamine inhibits prolactin release, promoting arousal (prolactin suppresses it post-orgasm).
Serotonin CRH (Corticotropin-Releasing Hormone): CRH drives stress responses, contrasting serotonin’s mood-stabilizing effects.

While stressful events naturally co-release several hormones that counteract the effects of orgasm-related chemicals, the idea of "exact opposites" is more functional than direct. The body’s stress response system broadly opposes the neurochemical state of orgasm, but not all antagonists are released at once in a single natural event. Adrenaline is also part of the sympathetic nervous system, which is active during both stress and sexual arousal.

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What is the polar opposite of an orgasm?